Open AccessDevelopment of Photoacoustic Probes for in Vivo Molecular Imaging
Author(s) -
Christopher J. Reinhardt,
Jefferson Chan
Publication year - 2017
Publication title -
biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.43
H-Index - 253
eISSN - 1520-4995
pISSN - 0006-2960
DOI - 10.1021/acs.biochem.7b00888
Subject(s) - photoacoustic imaging in biomedicine , molecular imaging , optical imaging , preclinical imaging , modality (human–computer interaction) , ultrasound imaging , optoacoustic imaging , superresolution , medical imaging , nanotechnology , ultrasound , in vivo , materials science , biomedical engineering , computer science , optics , medicine , physics , radiology , biology , artificial intelligence , microbiology and biotechnology , image (mathematics)
Photoacoustic (PA) imaging is an emerging, non-invasive imaging modality that encompasses attributes of both optical and ultrasound imaging. Because of the combination of optical excitation and acoustic detection, PA imaging enables high contrast and high resolution within deep tissue (centimeter depths). Recent advances in PA probe development have allowed for stimulus-responsive imaging in a variety of biological models with implications for basic, translational, and clinical sciences. This perspective highlights recent progress in the development of PA probes and their application to live-animal molecular imaging.