Open AccessTuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization
Author(s) -
Jacob A. Iannuzzelli,
J.P. Bacik,
Eric J. Moore,
Zhuofan Shen,
Ellen M. Irving,
David A. Vargas,
Sagar D. Khare,
Nozomi Ando,
Rudi Fasan
Publication year - 2022
Publication title -
biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.43
H-Index - 253
eISSN - 1520-4995
pISSN - 0006-2960
DOI - 10.1021/acs.biochem.2c00033
Subject(s) - thermostability , chemistry , protein engineering , heme , protein design , protein structure , amino acid , biocatalysis , cysteine , combinatorial chemistry , enzyme , stereochemistry , biochemistry , catalysis , reaction mechanism
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