Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain | Zendy

Shang Wu | Zendy; Limin Zhang | Zendy; Weizhi Wang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain

Author(s) -

Shang Wu,

Limin Zhang,

Weizhi Wang

Publication year - 2022

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.2c02223

Subject(s) - chemistry , peptide , blocking (statistics) , domain (mathematical analysis) , covid-19 , receptor , helix (gastropod) , oligopeptide , biophysics , virology , biochemistry , medicine , mathematical analysis , ecology , statistics , mathematics , disease , snail , infectious disease (medical specialty) , biology , pathology

A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research