Ratiometric pH-Responsive 19F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches | Zendy

Dawid Janasik | Zendy; K Jasiński | Zendy; Władysław P. Węglarz | Zendy; Ivan Němec | Zendy; Paweł Jewuła | Zendy; Tomasz Krawczyk | Zendy

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Ratiometric pH-Responsive ¹⁹F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

Author(s) -

Dawid Janasik,

K Jasiński,

Władysław P. Węglarz,

Ivan Němec,

Paweł Jewuła,

Tomasz Krawczyk

Publication year - 2022

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.1c04978

Subject(s) - chemistry , hydrazone , fluorine 19 nmr , proton nmr , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , proton , carbon 13 nmr , stereochemistry , physics , quantum mechanics

Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with 19 F NMR/MRI and 1 H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at 1 H and 19 F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF 3 group shifted by 1.8 ppm with 19 F NMR and a hydrazone proton shifted by 2 ppm with 1 H NMR.

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