Open AccessAddressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations
Author(s) -
Brian A. Lanman,
Andrew T. Parsons,
Stephan G. Zech
Publication year - 2022
Publication title -
accounts of chemical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.454
H-Index - 395
eISSN - 1520-4898
pISSN - 0001-4842
DOI - 10.1021/acs.accounts.2c00479
Subject(s) - atropisomer , axial chirality , chemistry , chirality (physics) , conformational isomerism , moiety , combinatorial chemistry , stereochemistry , enantioselective synthesis , organic chemistry , molecule , catalysis , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , quark
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