Open AccessLower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment
Author(s) -
Breton M Asken,
Lawren VandeVrede,
Julio C. Rojas,
Corrina Fonseca,
Adam M. Staffaroni,
Fanny M. Elahi,
Cutter A. Lindbergh,
Alexandra C. Apple,
Michelle You,
Sophia WeinerLight,
Nivetha Brathaban,
Natália C. Fernandes,
Adam L. Boxer,
Bruce L. Miller,
Howie Rosen,
Joel H. Kramer,
Kaitlin B. Casaletto
Publication year - 2021
Publication title -
journal of the international neuropsychological society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.074
H-Index - 127
eISSN - 1469-7661
pISSN - 1355-6177
DOI - 10.1017/s1355617721000813
Subject(s) - cohort , white matter , dementia , medicine , psychology , neuropsychology , neuropsychological assessment , glial fibrillary acidic protein , cognitive decline , executive dysfunction , voxel based morphometry , pathology , cognition , magnetic resonance imaging , neuroscience , disease , radiology , immunohistochemistry
There are minimal data directly comparing plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in aging and neurodegenerative disease research. We evaluated associations of plasma NfL and plasma GFAP with brain volume and cognition in two independent cohorts of older adults diagnosed as clinically normal (CN), mild cognitive impairment (MCI), or Alzheimer's dementia.