Open AccessHIV, Vascular Risk Factors, and Cognition in the Combination Antiretroviral Therapy Era: A Systematic Review and Meta-Analysis
Author(s) -
Elissa C. McIntosh,
Kayla Tureson,
Lindsay J. Rotblatt,
Elyse J. Singer,
April D. Thames
Publication year - 2020
Publication title -
journal of the international neuropsychological society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.074
H-Index - 127
eISSN - 1469-7661
pISSN - 1355-6177
DOI - 10.1017/s1355617720001022
Subject(s) - neurocognitive , medicine , meta analysis , odds ratio , clinical psychology , cognition , psychiatry
Mounting evidence indicates that vascular risk factors (VRFs) are elevated in HIV and play a significant role in the development and persistence of HIV-associated neurocognitive disorder. Given the increased longevity of people living with HIV (PLWH), there is a great need to better elucidate vascular contributions to neurocognitive impairment in HIV. This systematic review and meta-analysis examine relationships between traditional VRFs, cardiovascular disease (CVD), and cognition in PLWH in the combination antiretroviral therapy era.