Open AccessInteraction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men
Author(s) -
Riki Slayday,
Daniel E. Gustavson,
Jeremy A. Elman,
Audrey N. Beck,
Linda K. McEvoy,
Xin Tu,
Bin Fang,
Richard L. Hauger,
Michael J. Lyons,
Ruth McKenzie,
Mark SandersonCimino,
Hong Xian,
William S. Kremen,
Carol E. Franz
Publication year - 2020
Publication title -
journal of the international neuropsychological society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.074
H-Index - 127
eISSN - 1469-7661
pISSN - 1355-6177
DOI - 10.1017/s1355617720000570
Subject(s) - cognition , episodic memory , apolipoprotein e , verbal fluency test , psychology , effects of sleep deprivation on cognitive performance , neuropsychology , alcohol , developmental psychology , clinical psychology , medicine , psychiatry , disease , biology , biochemistry
Heavy alcohol consumption is associated with poorer cognitive function in older adults. Although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (ApoE) ε4 allele, a risk factor for Alzheimer's disease. We examined the relationship between alcohol consumption, ApoE genotype, and cognition in middle-aged adults and hypothesized that light and/or moderate drinkers (≤2 drinks per day) would show better cognitive performance than heavy drinkers or non-drinkers. Additionally, we hypothesized that the association between alcohol use and cognitive function would differ by ApoE genotype (ε4+ vs. ε4-).