Open AccessEpisodic Memory and Hippocampal Volume Predict 5-Year Mild Cognitive Impairment Conversion in Healthy Apolipoprotein ε4 Carriers
Author(s) -
Margaret Abraham,
Michael Seidenberg,
D. Kelly,
Kristy A. Nielson,
John L. Woodard,
J. Carson Smith,
Sally Durgerian,
Stephen M. Rao
Publication year - 2020
Publication title -
journal of the international neuropsychological society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.074
H-Index - 127
eISSN - 1469-7661
pISSN - 1355-6177
DOI - 10.1017/s1355617720000181
Subject(s) - subiculum , audiology , dementia , psychology , apolipoprotein e , temporal lobe , neuropsychology , cognition , medicine , hippocampus , cardiology , neuroscience , dentate gyrus , disease , epilepsy
The Apolipoprotein (APOE) ε4 allele increases the risk for mild cognitive impairment (MCI) and dementia, but not all carriers develop MCI/dementia. The purpose of this exploratory study was to determine if early and subtle preclinical signs of cognitive dysfunction and medial temporal lobe atrophy are observed in cognitively intact ε4 carriers who subsequently develop MCI.