Open AccessConduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample
Author(s) -
Scott Tillem,
May I. Conley,
Arielle BaskinSommers
Publication year - 2021
Publication title -
development and psychopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.761
H-Index - 171
eISSN - 1469-2198
pISSN - 0954-5794
DOI - 10.1017/s0954579421000237
Subject(s) - neurocognitive , psychology , functional magnetic resonance imaging , connectome , cognition , effects of sleep deprivation on cognitive performance , clinical psychology , developmental psychology , functional connectivity , psychiatry , neuroscience
Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development SM Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (β = .039, 95% CI corrected [.0027 .0771]), but lower Degree subcortical (β = -.052, 95% CI corrected [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (β = -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (β = -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect β = -.002, 95% CI [-.0044 -.0002]), and Degree subcortical mediated the relationship between CD and emotion recognition memory performance (indirect β = -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions.