Open AccessPreconditioning, but not postconditioning, with Sevoflurane reduces pulmonary neutrophil accumulation after lower body ischaemia/reperfusion injury in rats
Author(s) -
Robert G. Kalb,
Patrick Schober,
L. A. Schwarte,
J. Weimann,
S. A. Loer
Publication year - 2008
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1017/s0265021508003682
Subject(s) - medicine , sevoflurane , ischemia , reperfusion injury , anesthesia , neutrophile , pathophysiology , cardiology , inflammation
Aortic ischaemia and reperfusion may induce pulmonary sequestration of neutrophil granulocytes. Preconditioning and postconditioning with volatile anaesthetics confer protection against reperfusion injury in various organs, such as heart, kidneys or brain. We tested the hypothesis that pre- or postconditioning with Sevoflurane attenuates pulmonary neutrophil accumulation after ischaemia/reperfusion injury of the aorta.