Open AccessAn investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia
Author(s) -
Gabriella Iohom,
Martii Chonghaile,
John O’Brien,
Anthony J. Cunningham,
D F Fitzgerald,
Denis C. Shields
Publication year - 2007
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1017/s0265021507000476
Subject(s) - propofol , bispectral index , medicine , cyp2b6 , anesthesia , pharmacokinetics , genotype , pharmacodynamics , haplotype , pharmacology , biology , gene , cytochrome p450 , metabolism , cyp3a4 , biochemistry
The objectives of this study were, firstly, to characterize the inter-patient variability in the dose of propofol required to achieve a bispectral index <70 and 'time to eye opening' following propofol infusion and, secondly, to determine if the pharmacodynamic parameter 'time to achieve bispectral index <70' was influenced by genotype of the sex-linked drug receptor gene GABRE or if pharmacokinetic parameters such as clearance and 'time to eye opening' were influenced by the genotype of the metabolizing enzyme CYP2B6.