Open AccessDifferential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model*
Author(s) -
Ingrid Haller,
Philipp Lirk,
Christian Keller,
G. K. Wang,
Peter Gerner,
Lars Klimaschewski
Publication year - 2007
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1017/s0265021507000154
Subject(s) - desipramine , doxepin , amitriptyline , pharmacology , imipramine , tricyclic , neurotoxicity , tricyclic antidepressant , mianserin , medicine , behavioural despair test , potency , antidepressant , chemistry , toxicity , in vitro , endocrinology , biochemistry , hippocampus , alternative medicine , pathology
Tricyclic antidepressants are commonly employed orally to treat major depressive disorders and have been shown to be of substantial benefit in various chronic pain conditions. Among other properties they are potent Na+ channel blockers in vitro and show local anaesthetic properties in vivo. The present study aimed to determine their differential neurotoxicity, and that of novel derivatives as prerequisite for their potential use in regional anaesthesia.