Open AccessThe systemic absorption and disposition of levobupivacaine 0.5% after epidural administration in surgical patients: a stable-isotope study
Author(s) -
M. J. G. Simon,
Bernadette Veering,
Rudolf Stienstra,
Jack W. van Kleef,
Steven G. Williams,
G. M. McGUIRE,
A. G. L. Burm
Publication year - 2004
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1017/s0265021504006088
Subject(s) - levobupivacaine , medicine , pharmacokinetics , epidural administration , venous blood , absorption (acoustics) , anesthesia , deuterium , volume of distribution , isotope , pharmacology , analgesic , morphine , physics , quantum mechanics , acoustics
Absorption and disposition kinetics can be studied with a stable-isotope method. The aim of this study was to validate a stable-isotope method for levobupivacaine and to derive the relevant pharmacokinetics after epidural administration.