Open AccessAnterior hippocampal dysfunction in early psychosis: a 2-year follow-up study
Author(s) -
Maureen McHugo,
Suzanne N. Avery,
Kristan Armstrong,
Baxter P. Rogers,
Simon Vandekar,
Neil D. Woodward,
Jennifer Urbano Blackford,
Stephan Heckers
Publication year - 2021
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s0033291721001318
Subject(s) - psychosis , hippocampal formation , psychology , schizophrenia (object oriented programming) , psychiatry , longitudinal study , neuroscience , medicine , pathology
Cross-sectional studies indicate that hippocampal function is abnormal across stages of psychosis. Neural theories of psychosis pathophysiology suggest that dysfunction worsens with illness stage. Here, we test the hypothesis that hippocampal function is impaired in the early stage of psychosis and declines further over the next 2 years.