Open AccessHeritable anisotropy associated with cognitive impairments among patients with schizophrenia and their non-psychotic relatives in multiplex families
Author(s) -
Konasale M. Prasad,
Joshua Gertler,
Savannah Tollefson,
Joel Wood,
David R. Roalf,
Ruben C. Gur,
Laura Almasy,
Michael F. Pogue-Geile,
Vishwajit L. Nimgaonkar
Publication year - 2020
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s0033291720002883
Subject(s) - heritability , neurocognitive , fractional anisotropy , schizophrenia (object oriented programming) , white matter , correlation , psychology , genetic correlation , cognition , genetics , biology , genetic variation , medicine , psychiatry , geometry , mathematics , radiology , gene , magnetic resonance imaging
To test the functional implications of impaired white matter (WM) connectivity among patients with schizophrenia and their relatives, we examined the heritability of fractional anisotropy (FA) measured on diffusion tensor imaging data acquired in Pittsburgh and Philadelphia, and its association with cognitive performance in a unique sample of 175 multigenerational non-psychotic relatives of 23 multiplex schizophrenia families and 240 unrelated controls (total = 438).