Open AccessBoth unmedicated and medicated individuals with schizophrenia show impairments across a wide array of cognitive and reinforcement learning tasks
Author(s) -
Erin K. Moran,
James M. Gold,
Cameron S. Carter,
Angus W. MacDonald,
J. Daniel Ragland,
Steven M. Silverstein,
Steven J. Luck,
M Deanna
Publication year - 2020
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s003329172000286x
Subject(s) - schizophrenia (object oriented programming) , psychology , cognition , working memory , reinforcement learning , antipsychotic , cognitive psychology , cognitive remediation therapy , psychiatry , clinical psychology , computer science , artificial intelligence
Schizophrenia is a disorder characterized by pervasive deficits in cognitive functioning. However, few well-powered studies have examined the degree to which cognitive performance is impaired even among individuals with schizophrenia not currently on antipsychotic medications using a wide range of cognitive and reinforcement learning measures derived from cognitive neuroscience. Such research is particularly needed in the domain of reinforcement learning, given the central role of dopamine in reinforcement learning, and the potential impact of antipsychotic medications on dopamine function.