Open AccessDecreased functional connectivity of hippocampal subregions and methylation of the NR3C1 gene in Han Chinese adults who lost their only child
Author(s) -
Rongfeng Qi,
Yaping Luo,
Li Zhang,
Yifei Weng,
Wesley Surento,
Qiang Xu,
Neda Jahanshad,
Lingjiang Li,
Zhihong Cao,
Guang Ming Lu,
Paul M. Thompson
Publication year - 2020
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s0033291720000045
Subject(s) - hippocampal formation , dentate gyrus , glucocorticoid receptor , functional magnetic resonance imaging , psychology , methylation , posterior cingulate , hippocampus , neuroscience , medicine , glucocorticoid , gene , biology , genetics
Losing one's only child is a major traumatic life event that may lead to post-traumatic stress disorder (PTSD); however, the underlying mechanisms of its psychological consequences remain poorly understood. Here, we investigated subregional hippocampal functional connectivity (FC) networks based on resting-state functional magnetic resonance imaging and the deoxyribonucleic acid methylation of the human glucocorticoid receptor gene ( NR3C1 ) in adults who had lost their only child.