Open AccessSmaller total brain volume but not subcortical structure volume related to common genetic risk for ADHD
Author(s) -
Michael A. Mooney,
Priya Bhatt,
Robert Hermosillo,
Peter Ryabinin,
Molly A. Nikolas,
Stephen V. Faraone,
Damien A. Fair,
Beth Wilmot,
Joel T. Nigg
Publication year - 2020
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s0033291719004148
Subject(s) - putamen , brain size , endophenotype , polygenic risk score , psychology , attention deficit hyperactivity disorder , thalamus , caudate nucleus , brain morphometry , medicine , neuroscience , psychiatry , magnetic resonance imaging , biology , genetics , cognition , single nucleotide polymorphism , genotype , gene , radiology
Mechanistic endophenotypes can inform process models of psychopathology and aid interpretation of genetic risk factors. Smaller total brain and subcortical volumes are associated with attention-deficit hyperactivity disorder (ADHD) and provide clues to its development. This study evaluates whether common genetic risk for ADHD is associated with total brain volume (TBV) and hypothesized subcortical structures in children.