Open AccessReduced limbic microstructural integrity in functional neurological disorder
Author(s) -
Ibai Diez,
Benjamin Williams,
Marek Kubicki,
Nikos Makris,
David L. Perez
Publication year - 2019
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s0033291719003386
Subject(s) - fornix , stria terminalis , fractional anisotropy , corpus callosum , uncinate fasciculus , diffusion mri , psychology , white matter , cingulum (brain) , limbic system , medicine , neuroscience , amygdala , magnetic resonance imaging , hippocampus , radiology , central nervous system
Functional neurological disorder (FND) is a condition at the intersection of neurology and psychiatry. Individuals with FND exhibit corticolimbic abnormalities, yet little is known about the role of white matter tracts in the pathophysiology of FND. This study characterized between-group differences in microstructural integrity, and correlated fiber bundle integrity with symptom severity, physical disability, and illness duration.