Open AccessMaternal half-sibling families with discordant fathers: a contrastive design assessing cross-generational paternal genetic transmission of alcohol use disorder, drug abuse and major depression
Author(s) -
Kenneth S. Kendler,
Henrik Ohlsson,
Jan Sundquist,
Kristina Sundquist
Publication year - 2019
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s0033291719000874
Subject(s) - offspring , sibling , conduct disorder , psychopathology , psychology , alcohol use disorder , substance abuse , educational attainment , pregnancy , antisocial personality disorder , psychiatry , medicine , poison control , developmental psychology , injury prevention , genetics , alcohol , biology , biochemistry , environmental health , economics , economic growth
We introduce and apply an elegant, contrastive genetic-epidemiological design - Maternal Half-Sibling Families with Discordant Fathers - to clarify cross-generational transmission of genetic risk to alcohol use disorder (AUD), drug abuse (DA) and major depression (MD).