Open AccessExecutive dysfunction in depression in adolescence: the role of inflammation and higher body mass
Author(s) -
Naoise Mac Giollabhui,
Dominika Swistun,
Susan Murray,
Daniel P. Moriarity,
Marin Kautz,
Lauren M. Ellman,
Thomas M. Olino,
Christopher L. Coe,
Lyn Y. Abramson,
Lauren B. Alloy
Publication year - 2019
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s0033291719000564
Subject(s) - executive dysfunction , depression (economics) , body mass index , prospective cohort study , clinical psychology , cognition , psychology , medicine , affect (linguistics) , psychiatry , neuropsychology , communication , economics , macroeconomics
There is substantial evidence that many depressed individuals experience impaired executive functioning. Understanding the causes of executive dysfunction in depression is clinically important because cognitive impairment is a substantial contributor to functional impairment. This study investigated whether elevated levels of an inflammatory cytokine [interleukin-6 (IL-6)] and/or higher body mass index (BMI) concurrently and/or prospectively accounted for the relationship between depressive symptoms and impaired executive functioning in adolescents.