Open AccessLevels of early-childhood behavioral inhibition predict distinct neurodevelopmental pathways to pediatric anxiety
Author(s) -
Rany Abend,
Caroline Swetlitz,
Lauren K. White,
Tomer Shechner,
Yair BarHaim,
Courtney Filippi,
Katharina Kircanski,
Simone P. Haller,
Brenda E. Benson,
Gang Chen,
Ellen Leibenluft,
Nathan A. Fox,
Daniel S. Pine
Publication year - 2019
Publication title -
psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.857
H-Index - 209
eISSN - 1469-8978
pISSN - 0033-2917
DOI - 10.1017/s0033291718003999
Subject(s) - anxiety , amygdala , psychology , association (psychology) , temperament , early childhood , clinical psychology , developmental psychology , neuroscience , psychiatry , personality , social psychology , psychotherapist
Anxiety symptoms gradually emerge during childhood and adolescence. Individual differences in behavioral inhibition (BI), an early-childhood temperament, may shape developmental paths through which these symptoms arise. Cross-sectional research suggests that level of early-childhood BI moderates associations between later anxiety symptoms and threat-related amygdala-prefrontal cortex (PFC) circuitry function. However, no study has characterized these associations longitudinally. Here, we tested whether level of early-childhood BI predicts distinct evolving associations between amygdala-PFC function and anxiety symptoms across development.