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Neurodevelopmental outcome in children born to mothers wit hypertension in pregnancy: the significance of suboptimal intrauterine growth
Author(s) -
Kronenberg Mindy E,
Raz Sarah,
Sander Craig J
Publication year - 2006
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1017/s0012162206000430
Subject(s) - medicine , gestational age , pregnancy , gestational hypertension , pediatrics , gestation , obstetrics , appropriate for gestational age , reference range , gross motor skill , intrauterine growth restriction , motor skill , small for gestational age , genetics , biology , psychiatry
In this investigation of 45 children born to mothers with hypertension in pregnancy, our objective was to examine the role of a fetal risk factor (suboptimal intrauterine growth [SOIUG]) in determining developmental outcome. There were two groups of children: Group 1 ( n =26; 10 males, 16 females; mean testing age 56.77 mo [SD 13.03], range 41–82 mo; mean gestational age 32.96 wks [SD 2.24], range 27–38 wks; mean birthweight 1984.42g [SD 563], range 1046–3515g) without, and Group 2 ( n =19; 6 males, 13 females; mean testing age 57.63 mo [SD 14.86], range 40–84 mo; mean gestational age 34.21 wks [SD 2.10], range 29–39 wks, mean birthweight 1572g [SD 365], range 855–2690g) with SOIUG. We found that SOIUG was associated with a significant reduction in cognitive and motor skills ( p <0.05). Visuospatial ( p <0.01) as well as motor skills ( p <0.001) were linearly associated with the extent of intrauterine growth deficit when the latter was treated as a continuous variable. To conclude, an increase in intrauterine growth deficit is accompanied by a proportionate decline in quality of developmental outcome in children born to mothers with hypertension in pregnancy.