Open AccessThe utility of paired upper and lower respiratory tract sampling for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing in patients with artificial airways
Author(s) -
Eimear Kitt,
Daniela Davis,
Caryn Kerman,
Julia Shaklee Sammons,
Lori Handy,
Elizabeth Gallagher,
Kevin O’Callaghan,
Rebecca M. Harris,
Susan Coffin,
Louis M. Bell,
Kathleen Chiotos
Publication year - 2021
Publication title -
infection control and hospital epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.243
H-Index - 138
eISSN - 1559-6834
pISSN - 0899-823X
DOI - 10.1017/ice.2021.222
Subject(s) - covid-19 , respiratory tract , medicine , respiratory system , coronavirus , severe acute respiratory syndrome , betacoronavirus , respiratory tract infections , virology , disease , infectious disease (medical specialty) , outbreak
Early in the coronavirus disease 2019 (COVID-19) pandemic, the CDC recommended collection of a lower respiratory tract (LRT) specimen for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing in addition to the routinely recommended upper respiratory tract (URT) testing in mechanically ventilated patients. Significant operational challenges were noted at our institution using this approach. In this report, we describe our experience with routine collection of paired URT and LRT sample testing. Our results revealed a high concordance between the 2 sources, and that all children tested for SARS-CoV-2 were appropriately diagnosed with URT testing alone. There was no added benefit to LRT testing. Based on these findings, our institutional approach was therefore adjusted to sample the URT alone for most patients, with LRT sampling reserved for patients with ongoing clinical suspicion for SARS-CoV-2 after a negative URT test.