Open AccessHepatoprotective mechanism of lycorine against carbon tetrachloride induced toxicity in swiss albino mice – A proteomic approach
Author(s) -
Soundharrajan Ilavenil,
Dhanaraj Karthik,
Mariadhas Valan Arasu,
M Vijayakumar,
Srisesharam Srigopalram,
S. Arokiyaraj,
S. Ravikumar,
Ki Choon Choi
Publication year - 2015
Publication title -
asian pacific journal of reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 17
eISSN - 2305-0519
pISSN - 2305-0500
DOI - 10.1016/s2305-0500(15)30008-7
Subject(s) - lycorine , carbon tetrachloride , ccl4 , oxidative stress , chemistry , biochemistry , hsp60 , pharmacology , biology , heat shock protein , hsp70 , stereochemistry , organic chemistry , gene , alkaloid
Objective: To investigate the differential of protein expression in CCl4 induced mice treated with lycorine.Methods: The present study was carried out to identify the differentially expressed protein in carbon tetrachloride (CCl4) induced oxidative stress mice treated with lycorine (5 mg/kg. bw) using 2D gel and MALDI-TOF.Results: We observed many kinds of differentially expressed protein in experimental liver. Among these, three are much differently expressed protein which is identified as ATP synthase, regucalcin and HSP60; these proteins are involved in the ATP synthesis, calcium regulation and rescue the integrity cellular proteins respectively.Conclusions: This investigation provided a molecular mechanism of the lycorine during CCl4 induced oxidative stress in mice liver