Open AccessAntidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
Author(s) -
Mst. Hajera Khatun,
Mst. Luthfun Nesa,
Rafikul Islam,
Farhana Alam Ripa,
Al mamum,
Shahin Kadir
Publication year - 2014
Publication title -
asian pacific journal of reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 17
eISSN - 2305-0519
pISSN - 2305-0500
DOI - 10.1016/s2305-0500(14)60015-4
Subject(s) - alloxan , traditional medicine , phytochemical , chemistry , castor oil , pharmacology , medicine , diabetes mellitus , biochemistry , endocrinology
Objective: To assess the anti-diabetic and antidiarrheal activity of methanolic extract of Phyllanthus reticulates (P. reticulates) leaves in an animal model.Methods: Phytochemical screening of methanolic extract of P. reticulatus leaves has been performed. Antidiabetic activity have been done by OGTT, normoglycemic hyperglycemia and alloxan induced diabetic mice. Plant extracts (150 mg/kg and 300 mg/kg, b.w.) were administered orally in fasting glucose loaded mice with regard to normal control and in alloxan induced (110 mg/kg body weight i.p.) diabetic mice in comparison with reference drug Metformin hydrochloride (100 mg/kg) during 7 day test period. Antidiarrheal test was conducted by castor oil and magnesium sulfate.Results: Findings confirmed that the continuous post-treatment for 7 days with both extracts showed significant (P < 0.05) hypoglycemic activity in OGTT, normoglycemic and alloxan induced mouse models. Castor oil and Magnesium sulfate induced diarrheal test of the extract (200 and 400 mg/kg) has given significant effect in compairing to control diarrheal group.Conclusion: Methanolic extract of P. reticulatus leaves have shown significant antidiabetic and antidiarrheal properties