Open AccessEvaluation of safety and efficacy of Maa-Lact in lactating Holtzman rats
Author(s) -
Rohit Dhumal,
Nilakash Selkar,
Mukesh Chawda,
Kapil Thakur,
M.K. Vahalia,
Venu Gopal Jonnalagadda,
Geeta Vanage
Publication year - 2014
Publication title -
asian pacific journal of reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 17
eISSN - 2305-0519
pISSN - 2305-0500
DOI - 10.1016/s2305-0500(13)60177-3
Subject(s) - weaning , lactation , prolactin , medicine , adipose tissue , litter , body weight , zoology , physiology , endocrinology , biology , pregnancy , hormone , genetics , agronomy
Objective: To evaluate the safety & efficacy of Maa-Lact granules for its galactogougue activity in Holtzman rats and its effect on suckling pups.Methods: Group I rats were treated as control, group II and III rats were treated with 500 mg/kg, 1 000 mg/kg of Maa-Lact granules for 21 days. Weekly body weights of dams and pups were collected, litter survivability for 22 days and ocular blood samples were collected on 1st day of parturition and 21st day of post parturition for the estimation of prolactin levels. On 21st day blood samples were collected from retro-orbital sinus for haemotological and biochemical estimations. On the same day of weaning rats were sacrificed and subjected to necropsy and individual organ weights were recorded.Results: No significant difference in weekly food weight consumption, body weights between control & treated groups with normal clinical signs. There is no mortaly in dams throught the study period with no significant difference in pups weights. The percentage mortality in pups was 14.43 %, 14.07 %, and 13.42% in group I, group II and group III, respectively. The histopathological finding has shown that treated groups have less convulution and adipose tissue deposition along with increase in length and branching of lactiferous duct and alveolar size.Conclusion: Based on above results, it can be concluded that Maa-Lact posseses significant galctogogue activity