Elementary of animal model for percutaneous and ocular penetration

Models of animal are the most appropriate method for assessments of human in-vivo\udpercutaneous and ocular penetrations. Monkey and rodents are used for the same. There are\udseveral nuts and bolts of each one, so it is necessary to study each one separately. Monkey,\udporcine and guinea pig penetration are correlated with that of human skin. The skin of rodents,\udlupus, pigs, etc. has more penetration properties than human skin. Rabbit, goat and sheep eye\udare mostly used for ocular penetration. The researcher also used hen’s egg chorioallantoic\udmembrane test for ocular irritation study. The other animals’ cornea, cul-de-sac, eyeballs and\udprepared corneal epithelial models are very less in practice. Web-based alternative non-animal\udmodels are also available instead of animal models too. This article describes characteristics\udof monkeys, pigs, rats, rabbits, guinea pigs and hairless rodents, HuSki model, Cellophane®\udmembrane, egg membrane, gelatin membrane, animal models for ophthalmic delivery,\udhen’s egg chorioallantoic membrane test, prepared corneal epithelial models and web-based\udalternative non-animal database