Open AccessSynthesis and evaluation of antiviral activities of novel sonochemical silver nanorods against HIV and HSV viruses
Author(s) -
Mazyar Etemadzade,
Ameneh Ghamarypour,
Rezvan Zabihollahi,
Gelare shabbak,
Mozhgan Shirazi,
Hassan Sahebjamee,
Ali Vaziri,
Artin Assadi,
Mehdi Shafiee Ardestani,
Seyed Ataollah Sadat Shandiz,
Mohammad Reza Aghasadeghi
Publication year - 2016
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(16)61145-3
Subject(s) - nanorod , fourier transform infrared spectroscopy , nuclear chemistry , hela , scanning electron microscope , chemistry , thermogravimetric analysis , herpes simplex virus , silver nanoparticle , materials science , virus , virology , nanotechnology , nanoparticle , in vitro , chemical engineering , biochemistry , biology , organic chemistry , engineering , composite material
Objective: To evaluate the effect of novel sonochemical silver nanorods on HIV and herpes\udsimplex virus type 1 (HSV-1) viruses in human cervical cancer HeLa cells.\udMethods: The formation of silver nanorods conjugated with sodium 2-mercaptoethane\udsulfonate (Ag-MES) was characterized by scanning electron microscopy, Fourier transform\udinfrared spectroscopy and thermal gravimetric analysis. The antiviral activity of this Ag-MES\udwas examined against HIV and HSV-1 virus replication.\udResults: The characterizations of Ag-MES and physiochemical structure were determined by\udscanning electron microscopy, Fourier transform infrared spectroscopy and thermal gravimetric\udanalysis. Approximately entire viral replication was inhibited by Ag-MES at 10 µmol/mL\udconcentration. About 90% of HSV virions failed to replicate in the present of this concentration\udof nanorods. However, HIV showed more sensitivity to Ag-MES than HSV-1.\udConclusions: According to the obtained data, the synthesized sonochemical silver nanorod in\udthis study is a promising candidate for further drug discovery investigation