Thalassemia: Impact of consanguineous marriages on most prevalent monogenic disorders of humans

Thalassaemia is an inherited autosomal recessive disorder closely associated with\udconsanguineous marriages. A literature search was conducted with an aim to investigate\udthalassemia and consanguineous marriages. Articles were searched from Google Scholar\udand Pubmed information regarding thalassemia associated complications, epidemiology of\udthalassemia and association between consanguineous marriages and thalassemia, which was\udsubjected to contemplation. Thalassemia carrier rate varies differently in different regions of\udthe world. In Indian subcontinent and China, Central Asia, South Europe (also known as North\udMediterranean) and Arab Region, the thalassemia carrier rates were approximately 1%–40%,\ud4%–10%, 1%–19% and 3%, respectively. In Pakistan, the annual number of infants born with\udbeta thalassemia is the highest as compared to other countries from Eastern Mediterranean\udRegion. Although the management and control of thalassemia is a difficult task, it can easily\udbe achieved via the assistance of prenatal diagnosis and prevention programs. Consanguineous\udmarriages should be avoided to further limit the future burden of thalassaemia disease