Open AccessDetection of primary CMV infection in Sudanese pregnant women by IgG avidity test
Author(s) -
Mohammed Abubaker Altayeb,
Shamsaldin Ibrahim Mokhtar,
Mona Eltahir Adam,
Salahaldeen Isamail Mohammed,
Hassan Hussein Musa
Publication year - 2016
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(16)61137-4
Subject(s) - avidity , cytomegalovirus , antibody , immunology , medicine , immunoglobulin g , virology , immunoglobulin m , human cytomegalovirus , pregnancy , betaherpesvirinae , viral disease , herpesviridae , virus , biology , genetics
Objective: To diagnose primary cytomegalovirus (CMV) infection in pregnant women by\uddetermining CMV immunoglobulin G (IgG) avidity index.\udMethods: Ninety pregnant women with an average age of 23 years were studied. Their\uddemographic data were obtained along with blood samples. The anti-CMV immunoglobulin\udM (IgM) antibodies were determined on fully automated immuoanalyzer, while the CMV IgG\udavidity testing was carried out using avidity ELISA assay.\udResults: Among the pregnant women, 15.6% were in the first trimester, 30.0% in the second,\udand 54.4% in the third trimesters. Besides, 40.0% had chronic disease, while the other 60.0%\uddid not. Anti-CMV IgM antibodies and CMV IgG avidity test showed that 1.1% of the pregnant\udwomen were CMV IgM positive and 98.9% were CMV IgG positive, respectively. The avidity\udtest revealed the presence of low avidity of CMV IgG antibodies in 1.1% cases while 98.9%\udcases exhibited high avidity of CMV IgG antibodies.\udConclusions: CMV IgG avidity test was important to distinguish between CMV recent and past\udinfection rather than relying on IgG and IgM only, and IgM is not always indicative for recent\udor primary CMV infection