Open AccessModulation of cyptosporidiosis by CD4 levels in chronic diarrhoea HIV/AIDS individuals visiting Tarkwa Municipal hospital, Ghana
Author(s) -
Godwin Kwakye-Nuako,
Johnson Nyarko Boampong,
Mark Kweku Dong,
Dorcas ObiriYeboah,
Yeboah Kwaku Opoku,
Daniel Amoako-Sakyi,
Kwame Kumi Asare
Publication year - 2016
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(16)61127-1
Subject(s) - cyclospora , diarrhea , cryptosporidium , medicine , chronic diarrhea , enterocytozoon bieneusi , microsporidiosis , microsporidia , cryptosporidium parvum , immunology , gastroenterology , virology , feces , biology , protozoal disease , malaria , microbiology and biotechnology , spore
Objective: To investigate the role CD4+ levels play in controlling diarrhea conditions caused by\udintestinal coccidian infections among HIV/AIDS infected individuals visiting Tarkwa Municipal\udHospital.\udMethods: Fifty HIV/AIDS infected subjects with diarrhea conditions were enrolled into the\udstudy. Stool and blood samples were collected from each in two or three consecutive times to\udexamine intestinal coccidian and microsporidian infections using microscopy and also estimate\udCD4+ cells using BD FACSCount TM.\udResults: Fourteen of the participants had intestinal coccidian or microsporidian representing\ud28% while 72% of the participants had diarrhea of unknown origin. Cryptosporidium recorded\udthe highest prevalence of 42.86% whilst Cyclospora and Microsporidia equally recorded a\udprevalence of 28.57%. A significant protection against cryptosporidiosis was observed for\udCD4+ count above 200 cells/µL (χ2 = 6.522, P = 0.038), but not cyclosporiasis (P = 0.233) or\udmicrosporidiosis (P = 0.060).\udConclusions: This study has shown that CD4+ cells above 200 cell/µL of blood protect HIVinfected patients from cryptosporidiosis. Standardization of the association between CD4+\udcells and diarrhea condition caused by Cryptosporidium species is therefore suggested to\udserve as an indicator for prompt diagnosis and treatment of HIV-infected individuals with\udcryptosporidiosis