Open AccessAntioxidant and antidiabetic activities of the seed and leaf extracts of Chrysophyllum albidum
Author(s) -
Engwa Azeh Godwill,
Marcellus Unaegbu,
Aniakor Uchenna Esther,
Osuji Amarachukwu Gloria,
Agbafor Nwonu Kingsley,
Olayinka Ayobami Aiyegoro,
Anthony I. Okoh
Publication year - 2016
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(16)61102-7
Subject(s) - antioxidant , chemistry , traditional medicine , antioxidant capacity , food science , biochemistry , medicine
Objective: To investigate the antioxidant and antidiabetic activities of the seed and leaf extracts\udof Chrysophyllum albidum (C. albidum).\udMethods: After assessing the in vitro ferric reducing power and hydrogen peroxide scavenging\udactivities as well as the flavonoid and flavanol contents, the seed and leaf extracts were\udadministered to diabetic rats for 7 days. The animals were sacrificed and serum was obtained\udfor the determination of blood glucose level while liver sample was used for the quantification\udof glycogen level as well as lipidic peroxidation and catalase activity.\udResults: Seed and leaf extracts of C. albidum showed ferric reducing activity and very high\udhydrogen peroxide scavenging potential. After the administration of treatment in diabetic\udrats, there was a significant decrease (P < 0.05) in blood sugar level and a significant increase\ud(P < 0.05) in liver glycogen level in Groups 3 and 4 animals administered the leaf and seed\udextracts respectively compared to Group 1 (the negative control). Also, catalase activity and\udmalondialdehyde levels increased in Groups 3 and 4 administered the extracts compared to\udGroup 1 animals (the negative control). Flavonoids and flavanol were present and significantly\udhigher (P < 0.05) in the leaf than seed extract. In all, the leaf extract showed the greatest\udactivities.\udConclusions: These results suggest that the leaf and seed extracts of C. albidum possess both\udin vitro and in vivo antioxidant activities in scavenging free radicals as well as antidiabetic\udactivity, and as such, a potentially important compound in antidiabetic drug discovery