Open AccessScavenger receptor class-A plays diverse role in innate immunity, cell signaling and different pathologies
Author(s) -
Aamir Rana,
Syed Sajjad Sattar,
Afshann Shahzad,
Ghulam Muhammad Ali,
Yasir Waheed
Publication year - 2016
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(16)61088-5
Subject(s) - scavenger receptor , innate immune system , signal transduction , immunity , receptor , scavenger , microbiology and biotechnology , immunology , biology , immune system , genetics , biochemistry , lipoprotein , cholesterol , radical
Evidences have been increasingly provided to comfirm that lipid accumulation in cells\udcontributes to the progression of pathogeneses. The receptor-mediated lipid uptake is the\udcrucial step for lipid retention as scavenger receptors class-A (SR-A) is not controlled via\udnegative feedback by cytoplasmic cholesterol and therefore it plays a fundamental role in the\udformation of foam cells. Along with participation in apoptosis, SR-A presents very deceitful\udcharacteristics to control immune responses during age-related degenerative pathologies such\udas atherosclerosis and Alzheimer’s disease. It is henceforth undeniable that targeted inhibition\udof these receptors will be helpful in getting a step closer to individualized medicine. This\udreview unfolds current understanding of SR-A signaling with a focus on its role in apoptosis\udand immune regulation during different pathologies