Open AccessGC-MS analysis and cytotoxic activity of essential oils from the leaves of Abrus precatorius L. Gaertn
Author(s) -
Abdulkabir Oladele Oladimeji,
Oluwatoyin Babatunde,
Rukayat Titilayo Musa,
Fausat Adeola M'civer,
Abdulazeez Tunbosun Lawal,
Isiaka A. Ogunwande
Publication year - 2016
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(15)61050-7
Subject(s) - abrus precatorius , chemistry , essential oil , caryophyllene , traditional medicine , linalool , brine shrimp , food science , medicine
Objective: To determine the chemical constituents, cytotoxic activity and possible applications\udof the essential oils from the leaves of Abrus precatorius L. Gaertn.\udMethods: Hydro-distillation using Clevenger-type apparatus was employed to obtain the\udessential oils. Oil analysis was performed using an HP 6890 gas chromatograph coupled with\udan HP 5973 mass selective detector. The cytotoxicity bioassay was carried out using the brine\udshrimp lethality test.\udResults: Forty-five compounds were identified representing 100% of the oil. The\udprincipal components were γ-cadinene (19.1%), α-selinene (15.3%), α-cubenene (12.8%),\udβ-caryophyllene (8.2%), germacrene B (7.9%), α-copaene (7.7%) and linalool (6.3%). Others\udare caryophyllene oxide (5.5%), β-elemene (5.4%) and α-caryophyllene (4.0%). The oil was\udpotent with the LC50 value of 0.45 μg/mL.\udConclusions: The essential oil from the leaves of Abrus precatorius L. Gaertn. could hold\udpromise for future applications in the treatment of cancer-related diseases, in addition to flavor\udand fragrance industry