Open AccessIn vitro screening of snake venom against multidrug-resistant tuberculosis
Author(s) -
Sujay Kumar Bhunia,
Mrinmoy Sarkar,
Arpita Bhakta,
Antony Gomes,
Biplab Giri
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(15)60973-2
Subject(s) - venom , multiple drug resistance , naja , tuberculosis , medicine , in vitro , pharmacology , biology , microbiology and biotechnology , traditional medicine , drug resistance , pathology , ecology , biochemistry
The re-emergence of multidrug-resistant tuberculosis (MDR-TB) has brought to light the\udimportance of screening effective novel drugs. In the present study, in vitro activities of\uddifferent snake (Naja naja, Bungarus fasciatus, Daboia russelli russelli, Naja kaouthia)\udvenoms have been investigated against clinical isolate of MDR-TB strains. The treatment with\udall the venoms inhibited the mycobacterial growth for at least a week in common and two of\udthem (Naja naja and Naja kaouthia) showed significantly longer inhibition up to two weeks\udagainst the MDR-TB strain with single dose and a repetition of those two venoms exhibited\udinhibition up to more than four weeks