Evaluation of anticonvulsant and neuroprotective effects of camel milk in strychnine-induced seizure model

Objective: To discover the use of camel milk as an alternate medicine for the treatment and\udprevention of convulsions using strychnine-induced seizure model.\udMethods: Thirty animals were divided into three equal groups. Group I was on distilled water,\udGroup II was on camel milk for 15 days prior to experiment and Group III was on reference\uddrug diazepam. On the day of experiment, strychnine was administered in all treatment groups\udafter distilled water, camel milk and diazepam treatments respectively. Animals were observed\udfor 30 min for latency of seizure onset, frequency of convulsions and duration of jerks. The\udmortality rate was also evaluated for each group.\udResults: Camel milk treatment showed significant seizure protection as observed by delayed\udseizure onset (P ≤ 0.001), decreased total duration of convulsions (P ≤ 0.001) and mortality\udrate (P ≤ 0.001) when compared with Group I.\udConclusions: Anticonvulsant activity of camel milk could be due to potentiation of glycinergic\udand GABAergic activities both. Antioxidant activity can also amplify its antiepileptic activity.\udFurther studies are required to confirm the exact mechanism of action