Open AccessEvaluation of antinociceptive, anti-inflammatory and anxiolytic activities of methanolic extract of Terminalia citrina leaves
Author(s) -
Narhari Das,
Durajan Goshwami,
Md. Sharif Hasan,
Zobaer Al Mahmud,
Selim Raihan,
Md. Zakir Sultan
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(15)60875-1
Subject(s) - anxiolytic , nociception , traditional medicine , chemistry , terminalia , pharmacology , combretaceae , anti inflammatory , medicine , biochemistry , receptor
Objective: To investigate the antinociceptive, anti-inflammatory and anxiolytic effects of\udmethanolic extracts of Terminalia citrina (T. citrina) leaves (Family: Combretaceae).\udMethods: The antinociceptive activity was evaluated by acetic acid induced writhing method\udand radiant heat tail flick method while anti-inflammatory activity was evaluated by human red\udblood cell membrane stabilization method and anxiolytic activity by elevated plus maze model.\udResults: The methanolic extract of T. citrina leaves showed significant antinociceptive, antiinflammatory and anxiolytic effects in dose dependent manner compared to their respective\udstandard drugs.\udConclusions: The present study demonstrated that T. citrina possesses antinociceptive, antiinflammatory and anxiolytic effects