Open AccessAnalgesic, antipyretic, nephritic and antioxidant effects of the aerial parts of Bassia eriophora (Family: Chenopodiaceae) plant on rats
Author(s) -
Hasan Soliman Yusufoğlu
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(15)60836-2
Subject(s) - antipyretic , analgesic , malondialdehyde , antioxidant , chemistry , creatinine , uric acid , pharmacology , kidney , lipid peroxidation , traditional medicine , medicine , biochemistry
Objective: To study analgesic, antipyretic, renal and antioxidant effects of the aerial parts of\udBassia eriophora (Family: Chenopodiaceae) (B. eriophora), a wild plant in Saudi Arabia.\udMethods: Alcoholic extract (90%) of the aerial parts of B. eriophora was tested for analgesic,\udantipyretic, nephritic and antioxidant activities, to show their therapeutic potential. For\udanalgesic effect, hot plate and writhing methods were used while for antipyretic effect, rectal\udtemperature method was used. The renal protective effects and antioxidant properties were\uddetermined through CCl4-intoxicated animal method.\udResults: Animals treated with dose of 250 and 500 mg/kg body weight, after 90 min\udshowed significant analgesic effect (8.10 ± 0.18 and 8.10 ± 0.12) respectively, comparable\udto indomethacin (9.18 ± 0.22) in hot plate method, while in writhing method, the percentage\udreduction accounted for 55.14% and 68.38% at the dose of 250 and 500 mg/kg body weight\udrespectively. The antipyretic effect using rectal temperature method after 90 min, at the dose\udof 500 mg/kg body weight was 35.66 ± 0.13, comparatively more effective than indomethacin\ud(35.10 ± 0.22). The significant reduction of CCl4 on elevated creatinine, urea, uric acid, Ca, Na\udand K as well as increase on the depleted total protein after administration of the plant extract,\udindicated the safe use in kidney dysfunctions. The normalization of changed CCl4 intoxication,\udmalondialdehyde and nonprotein sulfhydryls levels designated antioxidant nature of this plant.\udThe histopathological evaluation of the kidney also revealed that B. eriophora alcoholic extract\udmay prevent the occurrence of kidney lesions.\udConclusions: B. eriophora may have analgesic, antipyretic and antioxidant activities, and may\udbe safely used in renal toxicity conditions. Furthermore, pharmacological and clinical studies\udwere required before therapeutic use