Open AccessAssessment of the haematological profile of children with malaria parasitaemia treated with three different artemisinin-based combination therapies
Author(s) -
Uchechukwu Madukaku Chukwuocha,
Onyirioha Misherk Chimezie,
Geoffrey Chima Nwakwuo,
Okorie Hope,
Dozie Ikechukwu Nosike Simplicius
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(15)60813-1
Subject(s) - artemisinin , amodiaquine , medicine , artesunate , malaria , lumefantrine , dihydroartemisinin , artemether , confidence interval , combination therapy , gastroenterology , immunology , plasmodium falciparum
Objective: To assess the haematological profile of children with malaria, treated with\udthree different artemisinin-based combination therapies in South Eastern Nigeria.\udMethods: Using a multistage sampling technique, blood samples were collected from\ud105 randomly selected malaria positive primary school children aged 6-13 years. Pre- and\udpost-assessment of their haematological profiles were respectively done on intervention of\udthree different artemisinin-based combination therapies.\udResults: Result showed a strong difference [(0.38 ± 0.31) g/dL] in haemoglobin levels\udwith the artesunate-amodiaquine (t = 7.30, P < 0.05). Dihydroartemisinin-piperaquine\ud(DP) and artemether-lumefantrine showed haemoglobin (t = 4.49, P < 0.05) with mean\uddifference [(0.64 ± 0.85) g/dL] and (t = 6.09, P < 0.05) with mean difference [(0.80 ±\ud0.78) g/dL] respectively. The mean difference of white blood cell was found to be negative\udbut significant with artesunate-amodiaquine (-1.07 ± 3.12) at 95% confidence intervel (CI)\ud(-2.14, 0.00) and artemether-lumefantrine (-0.36 ± 0.28) at 95% CI (-0.45, -0.26) interventions\udrespectively. Significant mean difference of neutrophils was only found for the DP\udinterventions (4.54 ± 8.30) at 95% CI (1.69, 7.40) while lymphocytes indicated a significant\udmean difference between the pre/post-interventions (-3.60 ± 9.34) at 95% CI (-6.81, -0.39)\udwith DP only.\udConclusions: Even though these findings do not indicate any life threatening events, they\udmay have some useful implications for investigating future non-infectious diseases of blood\udorigin. Further studies to determine the extent of involvement of malaria parasite as well as\uddrug interactions in haematological alterations vis-a-vis its implication for noncommunicable\uddisease are important