Open AccessEffects of α-tocopherol on the in vivo antitrypanosomal effects of phenolics-rich fraction of Khaya senegalensis stem bark
Author(s) -
Mohammed Auwal Ibrahim,
A. B. Aliyu,
Abdullahi Musa,
Isa Yunusa,
Ahmad Muhammad,
Blessing Alexander,
Bashir Musa,
Amiura Kakira,
Femi Omogoye
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(15)60811-8
Subject(s) - trypanosoma brucei , tocopherol , khaya , biology , pharmacology , anemia , traditional medicine , vitamin e , medicine , botany , biochemistry , antioxidant , gene
Objective: To investigate the effects of combined administration of a low dose of a phenolicsrich fraction of Khaya senegalensis (PFKS) stem bark with α-tocopherol on Trypanosoma\udbrucei brucei (T. brucei brucei) infection.\udMethods: Rats were divided into five groups of six animals, namely, normal control, uninfected\udbut treated with PFKS and α-tocopherol, infected control, infected and treated with PFKS and\udα-tocopherol (ITTF) and infected treated with diminazine aceturate. Rats in infected control,\udITTF and infected treated with diminazine aceturate were infected with T. brucei brucei while\udthe animals in uninfected but treated with PFKS and α-tocopherol and ITTF were treated with a\udcombination of PFKS (100 mg/kg body weight) and α-tocopherol (100 mg/kg body weight) for\ud8 days. At the end of the experiment, indices of anemia as well as hepatic and renal functions\udwere analysed.\udResults: The combined treatment significantly (P < 0.05) retarded the proliferation of\udT. brucei brucei in the infected animals compared to the infected group but could not\udcompletely eliminate the parasites from the bloodstream of infected animals. Furthermore, the\udtrypanosome-associated pathological changes such as anemia, hepatic and renal damages were\udsignificantly (P < 0.05) alleviated by the combination of PFKS and α-tocopherol.\udConclusions: Combination of a low dose of PFKS stem bark and α-tocopherol could be a\udtherapeutically active regimen against animal trypanosomiasis