Open AccessAnthelmintic potential of Helicteres isora bark extract against Pheretima posthuma
Author(s) -
Mahesh Bandappa Manke,
Shashikant C. Dhawale,
Prasad G. Jamkhande
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60789-1
Subject(s) - anthelmintic , albendazole , bark (sound) , traditional medicine , saline , biology , veterinary medicine , medicine , zoology , ecology , endocrinology
Objective: To evaluate anthelmintic potential of Helicteres isora (H. isora) bark extract in\udIndian adult earthworms.\udMethods: The H. isora bark and Indian adult earthworms (Pheretima posthuma) were\udcollected and authenticated by approved taxonomist. Earthworms were grouped and treated\udwith extract at concentration of 10, 20 and 50 mg/mL, albendazole of 10 mg/mL as standard\udand normal saline as a control. The paralysis time and death time was considered as indicator\udof anthelmintic activity.\udResults: All the extracts showed concentration dependent activity but significant activity was\udobserved at 50 mg/mL. The extract showed better activity at concentration of 50 mg/mL with\udparalysis time (12.54 min) and death time (16.55 min) when compared to standard albendazole.\udConclusions: The study revealed that the methanolic extract of H. isora bark have potent\udanthelmintic activity against Indian adult earthworms