Open AccessInhibitory effects of cinnamon-water extract on human tumor cell lines
Author(s) -
Nazila Ariaee-Nasab,
Zahra Vahedi,
Fatemeh Vahedi
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60768-4
Subject(s) - hela , dna fragmentation , apoptosis , fragmentation (computing) , chemistry , mtt assay , cell culture , inhibitory postsynaptic potential , cell , traditional medicine , cell growth , mcf 7 , pharmacology , biochemistry , biology , cancer cell , medicine , programmed cell death , human breast , cancer , genetics , ecology , neuroscience
Objective: To question the inhibitory effect of cinnamon-water extract (CWE) on four human\udtumor cell lines (AGs, HeLa, MCF-7 and MDA-MB234). Naturally, compounds are an important\udsource for clinical proposes. Cinnamon, a plant-derived spice, is widely used as a food additive\udand has been attracted many researches in recent years to find its pharmaceutical benefits.\udMethods: In order to find the answer to this subject, the water extract of cinnamon was prepared\udand cell proliferation was evaluated using MTT assay. The effect of apoptosis was investigated by\udDNA fragmentation analysis.\udResults: The inhibitory effect of CWE on the growth of the cells was significant. DNA\udfragmentation was found in cultured AGs and MCF-7 cell lines treated by CWE.\udConclusions: This study showed the anti-neoplastic activity of CWE on tumor cell lines