Open AccessIn vivo anti-androgenic, anti-estrogenic and antioxidant activities of the aqueous extract of Eremomastax speciosa
Author(s) -
Richard Simo Tagne,
Bruno Phélix Telefo,
Sylvain Nguedia Njina,
Bayala Bala,
Stéphanie Marie Chekem Goka,
Didiane Mefokou Yemele,
Landry Lienou Lienou,
Gildas Tetaping Mbemya,
Nathalie Jiatsa Donfack,
Armel Hervé Nwabo Kamdje,
Paul Fewou Moundipa
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60765-9
Subject(s) - catalase , acid phosphatase , antioxidant , prostatic acid phosphatase , testosterone (patch) , superoxide dismutase , in vivo , endocrinology , medicine , chemistry , ovariectomized rat , alkaline phosphatase , prostate , pharmacology , biology , estrogen , biochemistry , enzyme , cancer , microbiology and biotechnology
Objective: To evaluate the in vivo anti-androgenic, antioxidant activity and anti-estrogenic\udactivities of Eremomastax speciosa (E. speciosa) in order to find new method for fighting against\udchronic diseases such as cancer.\udMethods: Evaluations of antiandrogenic and antioxidant activities were carried out on male rate\udreceiving simultaneous daily administration of testosterone and different doses of aqueous extract\udof E. speciosa, during a period of 10 d. The evaluation of antiestrogenic activity was carried out on\udmature ovariectomized female rats receiving simultaneous daily administration of estradiol and\uddifferent doses of extract, for a week. Then reproductive organs were weighted, levels of prostatic\udacid phosphatase, superoxide dismutase and catalase as well as some hematologic parameters\udwere measured.\udResults: The treatment significantly reduced (P<0.01 ) the weight of ventral prostate, penis,\udCowper’s gland and the level of serum prostatic acid phosphatase; while a significant decrease\ud(P<0.01) of the catalase activity was observed. A significant increase (P<0.05) in the lymphocyte\udnumber and significant decrease of monocyte (P<0.05) were noticed. The uterine relative weight\udwere significantly reduced (P<0.01).\udConclusions: Generally, these results denote the antiandrogenic, antiestrogenic and\udimmunomodulatory potential of E. speciosa