Open AccessIn vitro antihelmintic activity of bark extract of Cinnamomum bejolghota (Buch.-Ham.) in Indian adult earthworm (Pheretima posthuma)
Author(s) -
Barnali Gogoi,
Bibhuti Bhusan Kakoti,
Nilutpal Sharma Bora,
Priyanka Yadav
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60759-3
Subject(s) - bark (sound) , albendazole , cinnamomum , traditional medicine , saline , aqueous extract , crude drug , chemistry , biology , medicine , anesthesia , ecology , alternative medicine , traditional chinese medicine , pathology , cassia
Objective: To carry out an exhaustive study with a view to substantiate the therapeutic potential\udof methanolic and aqueous extract of bark of Cinnamomum bejolghota (C. bejolghota) against\udPheretima posthuma which is used as experimental model for helmintic.\udMethods: Thirty-six adult earthworms of 3.5-5.0 cm length were collected from university\udcampus of Dibrugarh. Nine groups containing four worms in each group were divided for the\udexperiment. About 0.9% (w/v) of normal saline solution, 25 mg/mL, 50 mg/mL, 100 mg/mL each of\udstandard drug albendazole and methanolic, aqueous extract of bark of C. bejolghota were freshly\udprepared before commencement of the study. Earthworms were observed for paralysis and death\udtime which is recorded in minute.\udResults: Crude methanolic extract with concentrations of 25 mg/mL, 50 mg/mL and 100 mg/mL\udproduced dose-dependent paralysis. All results were expressed as the mean依SEM using Oneway ANOVA. The difference in values at P<0.01 was considered as statistically significant.\udConclusions: From the investigation, conclusion can be drawn that the methanolic bark extract\udof C. bejolghota showed better activity than aqueous extract of the same to treat intestinal worm\udinfections. In comparison with the standard drug albendazole, methanolic bark extract of the\udplant showed significant antihelminthic activity