Open AccessCNS activity of leaves extract of Calotropis gigantea
Author(s) -
Santosh Ghule,
G. Vidyasagar,
Anil Bhandari,
Praveen Kumar Sharma,
Atul Parashuram Gunjal
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60755-6
Subject(s) - anticonvulsant , gigantea , muscle relaxant , sedative , strychnine , muscle relaxation , chemistry , acute toxicity , pharmacology , traditional medicine , toxicity , medicine , anesthesia , biology , botany , epilepsy , organic chemistry , psychiatry
Objective: To study central nervous system activity of ethanolic extract of leaves of Calotropis\udgigantea (C. gigantea) (Asclepiadaceae), such as anticonvulsant, sedative and muscle relaxation\udactivity.\udMethods: The ethanolic extract of C. gigantea administered orally in experimental animals at\uddifferent doses 100, 200 and 500 mg/kg body weight. The anticonvulsant properties were studied on\udmaximal electroshock test and strychnine-induced convulsions model. Sedative property studied\udusing actophotometer and skeletal muscle relaxant property studied using rota rod.\udResults: This extract protected rats against maximal electroshock induced seizures, but had no or\uda moderate effect only against strychnine-induced seizures. Locomotor activity in mice found to\udbe decreased and motor coordination was also decreased. The acute toxicity study revealed safely\udof the extract up to a dose of 2 000 mg/kg.\udConclusions: With these effects, the leaves of C. gigantea possess anticonvulsant sedative and\udmuscle relaxant effect that might explain its use as a traditional medicine