Open AccessAnalgesic and anti-inflammatory properties of the fruits of Vernonia anthelmintica (L) Willd.
Author(s) -
Alok Pandey,
Deepak Dash,
Shailendra Kela,
Shubhangi Dwivedi,
Prashant Tiwari
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60750-7
Subject(s) - carrageenan , analgesic , traditional medicine , anti inflammatory , chemistry , in vivo , pharmacology , medicine , food science , biology , microbiology and biotechnology
Objective: To evaluation of analgesic and anti-inflammatory properties of the fruits of Vernonia\udanthelmintica (L) Willd. (V. anthelmintica).\udMethod: Hot plate method in mice, acetic acid induced writhing response in mice, tail\udimmersion test and carrageenan-induced paw edema in rats and cotton pellet induced granuloma\udin rats method were used for screening analgesic and anti-inflammatory properties of the fruit of V.\udanthelmintica (family: Asteraceae).\udResults: The result of the study showed that the ethanolic extract of V. anthelmintica (100 and\ud200 mg/kg body weight, p.o. ) fruits possed peripheral and central analgesic activity in animal\udmodel. The V. anthelmintica fruits extract showed in vivo anti-inflammatory activity on acute and\udchronic anti-inflammatory activity models in rats.\udConclusions: On the basis of result it can be concluded that saponins, steroids, tannins and\udflavonoids are the major constituents that are present in the fruits of V. anthelmintica which may\udbe responsible for its analgesic and anti-inflammatory activity