Open AccessEvaluation of CA-125 and other biochemical parameters in premenopausal and postmenopausal women with ovarian cancer: a hospital based study from Western Nepal
Author(s) -
C. Thanpari,
Neelu Yadav,
Roshan Takhelmayum,
Mukesh Kumar Shrewastwa,
Rabindra Kumar Mittal,
Pradeep Thapa
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60713-1
Subject(s) - medicine , endocrinology , triglyceride , cholesterol , ovarian cancer , cancer , menopause , breast cancer , postmenopausal women , lipid profile
Objective: To assess the status of carbohydrate antigen 125 (CA-125) and other biochemical\udparameters in premenopausal and postmenopausal ovarian cancer patients.\udMethods: Total 64 cases, out of which 43 premenopausal and 21 postmenopausal ovarian cancer\udpatients were included in the study. Twenty-five premenopausal and twenty postmenopausal\udage-matched healthy control subjects were selected. The variables collected were age, CA-\ud125, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density\udlipoprotein cholesterol (LDL-C), blood sugar, adenosine deaminase (ADA) and vitamin E. The data\udwas analyzed by using Statistical Package for the Social Sciences for Windows Version 16.0.\udResults: In premenopausal women, significant differences were noted for CA-125 (P<0.005),\udtriglycerides (P<0.009), HDL-C (P<0.001 ), blood sugar (P<0.001 ) and ADA (P<0.002) and in\udpostmenopausal women, significant differences were noted for CA-125 (P<0.001), triglycerides\ud(P<0.001), blood sugar (P<0.001), ADA (P<0.005) and vitamin E (P<0.002) when compared with\udcontrols. Insignificant results were found for total cholesterol (P=0.100), LDL-C (P=0.104) and\udvitamin E (P=0.142) in premenopausal women and total cholesterol (P=0.670), HDL-C (P=0.472) ,\udLDL-C (P=0.272) in postmenopausal women when compared with healthy control subjects.\udConclusions: Evaluation of CA-125 and other biochemical parameters may be important for\udcontrol of ovarian cancer and to improved survival rate