Open AccessPredictors of scrub typhus: a study from a tertiary care center
Author(s) -
Vijay K. Agarwal,
Gangireddy Krishna Mohan Reddy,
Malla Rama Krishna,
Garalapati Ramareddy,
Prusti Saroj,
Vishal Bandaru
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60704-0
Subject(s) - scrub typhus , eschar , medicine , odds ratio , meningoencephalitis , confidence interval , glasgow coma scale , orientia tsutsugamushi , surgery , pathology
Objective: To document the clinical and laboratory findings of scrub typhus infection and to\uddetermine the prognostic factors of the disease.\udMethods: Retrospective data were collected from 96 patients with scrub typhus infection, from\udJanuary 2012 to December 2013, at Yashoda hospital, Hyderabad. Prognostic factors for severe\udscrub typhus were analyzed by a multivariate analysis.\udResults: Out of 96 patients, men were 47 (48.9%) and median age was 39 years. Patients with low\udsocioeconomic status were 53 (55.3%). Among the 96 patients 46 (47.9%) had severe scrub typhus,\ud50 (52.1%) had mild severe scrub typhus. Two patients (2%) died. Symptoms of cough (P=0.001),\udpresence of eschar (P<0.001), Glasgow coma scale (GCS) below 12 (0.04), hepatomegaly (P=0.0001),\udsplenomegaly (P=0.000 1), and meningoencephalitis (P=0.01), were significantly associated with\udsevere scrub typhus. Multivariate analysis showed presence of eschar (odds 2.5; 95% confidence\udinterval (CI) 1.1-8.5), hepatomegaly (odds 1.9; 95% CI 1.1-3.8), meningoencephalitis (odds 4.8;\ud95% CI 1.1-21.8), GCS<12 (odds 1.8; 95% CI 0.5-2.4) and cough (odds 1.5; 95% CI 0.7-3.5) to be\udsignificantly associated with severe scrub typhus.\udConclusions: In our study, eschar, hepatomegaly, meningoencephalitis, poor GCS and cough\udwere significantly associated with severe scrub typhus